Parkinson’s is a progressive neurodegenerative disorder having no known cause, typically with onset later in life. Prevalence in the 60-69-year-old population is estimated to be approximately 1.0%, rising to 2.7% in those over 80. There are more than one million people living with Parkinson’s today in Europe; with an ageing population this figure is forecast to double by 2030. The condition is characterised by difficulty in moving and tremor, as well as psychiatric issues. It leads to a progressive reduction in the quality of life and those affected require increasing care. This imposes a significant socioeconomic burden which currently amounts to €13.9 billion of healthcare expenditure annually.
There is no cure for Parkinson’s yet. The current ‘gold standard’ medication, levodopa, was introduced in 1967, with few new therapeutic agents being registered since then. As such, there is an urgent need to develop new and better treatments. However, despite clinical strategies remaining largely unchanged over the past 50 years, our understanding of the disease mechanisms in Parkinson’s has advanced dramatically, revealing novel druggable targets. Hence, the disorder is in need of extra investment to translate these exciting opportunities into life changing therapies for patients.
In addition to genetic mutations, a potential risk factor for Parkinson’s disease is exposure to some toxins or herbicides, including diquat. In 2015, the European Food Safety Agency (EFSA) declared the herbicide to be potentially harmful and indicated it should be banned. The European Commission did not submit the proposal to the ScoPAFF, and invited EFSA to revise its opinion.
The workshop aims to look at the causes of Parkinson’s disease as well as possible ways forward, both clinically, but also on a political level, notably through the upcoming Horizon Europe research framework programme.
This workshop is organised by the European Chemical Society (EuChemS), the European Federation of Medicinal Chemistry (EFMC) and chaired by Member of the European Parliament Pavel Poc.
Please keep an eye on this page as it will be updated with further information.
09:00 – 12:00, 8 November 2018; Room: ASP A5E2, European Parliament, Brussels
09:00 – Welcome by the chairing MEP Pavel Poc (S&D)
09:05 – Introduction by Pilar Goya, EuChemS President
09:10 – Introduction by Yves P. Auberson, EFMC President
09:20 – Current treatment of Parkinson’s disease – Per Svenningsson, Karolinska Institute
09:30 – Causes for Parkinson’s disease – Roberto Cilia, Parkinson Institute
09:45 – Setting the basis for future health risk assessments: A case study on Parkinson disease and paraquat – Jose Tarazona, Head of EFSA’s Unit on Pesticides
09:55 – European Commission speaker (to be confirmed)
10:05 – New targets and drug discovery – Uli Hacksell, Marina Biotech
10:20 – Animal models and Parkinson’s disease – Angela Cenci Nilsson, Lund University
10:30 – Clinical aspects, new biomarkers (speaker to be confirmed)
10:40 – Horizon Europe Missions in health area – Nineta Hrastelj, EuChemS General Secretary
10:50 – Discussions and Q&A
Member of the European Parliament (S&D)
Per Svenningsson is Professor and Senior Physician at the movement disorders section of the Neurology department at Karolinska Institute. Besides being a medical doctor, he is trained in basic pharmacology. He has been the principal investigator of several clinical trials for the development of novel therapies against various symptoms of Parkinson´s disease. The studies include novel therapies for disease modification and against levodopa-induced dyskinesias and dementia.
European Food Safety Agency (EFSA), Head of EFSA’s Unit on Pesticides
Doctor in Veterinary Medicine with a PhD in Toxicology, Jose Tarazona started his professional career as Assistant Professor of Toxicology at the Complutense University in Madrid. From 1982 to 2009 Dr Tarazona was a researcher at the Spanish National Institute for Agriculture and Food Research and Technology (INIA). His scientific career was complemented with managerial responsibilities as Head of the Division of Environmental Toxicology and Director of the Department of the Environment. Author of over 250 scientific publications, editor of several reference books including the Encyclopaedia of Toxicology, from 2009 to 2013 he worked for the European Chemicals Agency (ECHA), first as Chair of the Committee for Risk Assessment and later as Scientific Chair of the Evaluation Directorate.
Marina Biotech, Inc
Dr Hacksell is Chairman of the Board of directors of Cerecor Inc. and Marina Biotech. He is a member of the Board of Directors of Medivir, Index Pharmaceuticals , Beactica and Uppsala University. Dr Hacksell served as CEO of ACADIA Pharmaceuticals from 2000-2015 where he was leading the development of pimavanserin, currently marketed in the US as Nuplazid, a medicine for psychosis associated with Parkinson’s disease. In the 1990s Dr Hacksell held senior positions at Astra AB. Earlier in his career, he was Professor of Organic Chemistry at Uppsala University and served as Chairman of the European Federation of Medicinal Chemistry.
EuChemS General Secretary
Dr. Nineta Hrastelj is the Secretary-General of the European Chemical Society (EuChemS) since 2011. She has worked at senior management and scientific positions in private and public sectors, both at the national and at the European level. She completed her PhD at the University of Ljubljana in Slovenia. Her research topics cut horizontally across analytical chemistry, chemometrics and metrology, including infrastructure aspects. She is author, co-author and editor of many publications in research and education as well as policy related topics of general concern. Her contributions were recognised through several awards.