The inaugural ELRIG meeting on Therapeutic OLIGOs combined with the 8th European Chemical Biology Symposium (ECBS) will be held on May 9-11 at the beautiful AstraZeneca R&D site in Gothenburg. This interactive 3-day event will host leading scientists from academia, industry and the vendor community to discuss recent advancements in the discovery of therapeutic OLIGOs and in the Chemical Biology research field in Europe and internationally. The ECBS part of the meeting is co-organized by EU-OPENSCREEN and the EuChemS Division of Chemistry in Life Sciences, and includes contributions from key academic chemical biology research groups in Europe. Our ambition is to create an open access meeting and an inspiring environment for networking between biologists and chemists to fuel cross-fertilisation between research areas.
OLIGOs such as ASOs, siRNAs and other mRNA-targeted therapeutics are impacting patients daily. To further expand the scope of these drug modalities the field is exploring new ways to formulate and distribute the cargo to improve the reach of additional disease-relevant tissue. Efforts include various ways of targeting the delivery, for example by conjugating the cargo to functional groups that interact with specific cell types. This is one area in which developments interplay with the field of chemical biology, where the aim is to exploit chemistry for the purpose of understanding and manipulating biology. With the recent announcement of the latest Nobel Prize in Chemistry for bio-orthogonal chemistry and click chemistry, there is more reason than ever to discuss the next advancements that will impact our understanding of and man-made changes to biology. This meeting will explore these opportunities and challenges in six focus areas as outlined at the web page (https://www.elrig.org/portfolio/elrigs-therapeutic-oligos-european-chemical-biology-symposium-2023/).