Does the Dose Make the Poison?

A new European Food Safety Agency (EFSA) external scientific report contributes to the debate on non-monotonic dose response (NMDR) results from toxicity studies, according to Prof Anthony Hardy, Chair of EFSA’s Scientific Committee. The view “the dose makes the poison” used in conventional hazard assessment implies a consistent increase in effects along the dose range, i.e. a monotonic dose response. For an NMDR effect, however, the response could both increase and decrease as the dose increases, resulting in, for example, U-shaped or inverted U-shaped curves when plotted on a graph.

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